Binding and neutralizing antibody responses to SARS-CoV-2 in very young children exceed those in adults
Related People: Ruth A. Karron, MD , Elizabeth Schappell, MSN, RN, CCRP
Related Research: SEARCh Study
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SARS-CoV-2 infections are frequently milder in children than adults, suggesting that immune responses may vary with age. However, information is limited regarding SARS-CoV-2 immune responses in young children.
We compared receptor binding domain–binding antibody (RBDAb) titers and SARS-CoV-2–neutralizing antibody titers, measured by pseudovirus-neutralizing antibody assay in serum specimens obtained from children aged 0–4 years and 5–17 years and in adults aged 18–62 years at the time of enrollment in a prospective longitudinal household study of SARS-CoV-2 infection.