Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children

A major effort has been directed at development of a live-attenuated RSV vaccine to avoid the RSV disease enhancement previously observed with the formalin-inactivated RSV vaccine. Disease enhancement has not been observed with live-attenuated RSV vaccine candidates or replicating vaccine vectors. Important potential advantages of intranasal live-attenuated RSV vaccines include induction of a spectrum of protective and immunoregulatory mucosal and systemic immune responses

Determining the outcomes of interventions to prevent respiratory syncytial virus disease in children: what to measure?

Respiratory syncytial virus (RSV) is the most common cause of viral acute lower respiratory tract illness (LRTI) in young children, and a major cause of hospital admissions and health-care utilisation globally. Substantial efforts have been made to develop RSV vaccines and vaccine-like monoclonal antibodies to prevent acute RSV LRTI. Prevention of acute disease could improve long-term lung health, with potential effects on wheezing, asthma, and chronic lung disease. This Personal View describes assessments that should be initiated during clinical trials and continued after licensure to fully evaluate the effect of RSV preventive interventions.

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