HIV Investigational Treatment Study (CIR 381)

Study Details

The HIV Pandemic has killed more than 44 million people and there are about 1.3 million new HIV infections reported globally every year. [WHO, 2025]

The Johns Hopkins CIR is looking for volunteers to participate in a Phase 1 outpatient clinical trial to test a new potential treatment for HIV. The purpose of this clinical trial is to assess the safety of the drug and to evaluate its ability to block HIV from infecting cells. The clinical trial is around 9 months long and requires the following:

• 1 screening visit
• 1 investigational drug administration visit
• 13 follow up visits
• 1 wellbeing phone call (additional phone calls may be required for some participants).

Eligibility for study participation will be confirmed by a clinical trial clinician. People who are eligible and enrolled will participate in clinical trial visits that may include blood draws, physical exams, vital signs and pregnancy prevention counseling. All study requirements and procedures will be reviewed with study participants during the informed consent process.

Eligible people may receive reimbursement up to $2520 for time and travel .