Director’s Message

Dr. Ruth A. Karron

Director's Message: Dr. Ruth A. Karron

Welcome to the Center for Immunization Research website!  Thank you for your interest in learning more about our center and the important work we do to facilitate the development of novel vaccines.  Our faculty and staff are committed to the local and global expansion of research activities in the areas of vaccine development, evaluation and policy.

Administering licensed vaccines is a safe and inexpensive way to prevent disability and death caused by infectious diseases.  However, every year children and adults all over the world continue to suffer from diseases for which there are no effective vaccines.  At the CIR, we believe that developing new vaccines is necessary to save lives.  For more than 25 years, I’ve had the pleasure of working alongside many talented faculty and staff members as the principal investigator of many studies at the center, and became its director in 2007.

The CIR’s study teams are dedicated to the safe and ethical conduct of phase I and II clinical vaccine trials in three main categories: pediatric studies, flavivirus plus studies and mucosal and vaccine challenge (MVAC) studies.  Each team is comprised of Johns Hopkins Bloomberg School of Public Health faculty, research nurses, study coordinators and research assistants who are devoted to the CIR’s mission to facilitate the development of new vaccines of global importance.  Collectively, we have conducted clinical vaccine trials for respiratory syncytial virus [RSV], human metapneumovirus [HMPV], influenza, and parainfluenza [PIV], flavivirus vaccines (dengue virus, West Nile virus and Zika), ebola, enteric vaccines (norovirus, enterotoxigenic E. coli (ETEC), Shigella and many other diseases and viruses.

CIR faculty members are leaders in the world of vaccine research and have laboratory as well as clinical trials expertise in our disease fields of interest.  Many of our faculty members serve on national and international committees to advance vaccine research efforts and share knowledge gained by the conduct of our own research.  We work closely with our partners at the NIAID/NIH, the Gates Foundation, US Department of Defense (DoD) and industry to develop innovative clinical and laboratory methods for the evaluation of vaccines.

Please take a moment to peruse our site.  There is a lot of important information about clinical vaccine research, educational information about the viruses and diseases we study, our faculty and staff, and upcoming clinical trials.  I hope that you enjoy your visit and the information we provided.


Ruth A. Karron, MD
Director of the Center for Immunization Research
Professor of International Health
Johns Hopkins Bloomberg School of Public Health


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